Chronic Kidney Disease
Continuing Education Credits
This course provides essential background on Chronic Kidney Disease (CKD) for the practicing clinical laboratorian. Emphasis is placed on the National Kidney Foundation-Kidney Disease Outcomes Quality Initiative (NKF-KDOQI) review and commentary of the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines, with focus on the laboratory testing associated with diagnosis and monitoring of the disease.
Objectives
- Describe the frequency, risk factors, classification, and public health implications of chronic kidney disease (CKD).
- Name and describe the use of common serum and urinary biomarkers used to diagnose and evaluate CKD.
- Describe the use and limitations of major calculations employed in estimating glomerular filtration rate.
- List treatment options to control progression of CKD.
Course Outline
- Chronic Kidney Disease
- Introduction
- Renal Anatomy & Function
- The Nephron
- Chronic Kidney Disease
- Epidemiology
- Risk Factors
- Match the correct organization to each statement.
- Which disease or factor is the current leading cause of CKD worldwide?
- True or False: According to KDIGO guidelines, CKD may be diagnosed if abnormalities in kidney structure or function have been present for more than three months.
- Laboratory Testing
- Diagnostic Tests for Chronic Kidney Disease
- Glomerular Filtration Rate
- Glomerular Filtration Rate
- Direct Measurement of the GFR
- Direct Measurement of the GFR, continued
- Calculated Estimates of GFR
- True or False: Decreases in GFR may be caused by both benign and pathological conditions.
- Which of the following tests is commonly used to assess the GFR?
- Creatinine
- Demographic Effects on Creatinine Generation
- Effects of Age on GFR
- Measurement of Creatinine
- Measurement of Creatinine, continued
- Creatinine Assay Standardization
- Which of the following factors influences creatinine concentration?
- Match the description of the following creatinine assays. Answers may be used more than once or not at all.
- Cystatin C
- Creatinine Clearance
- Cockcroft-Gault Equation
- Modification of Diet in Renal Disease (MDRD) Equation
- Chronic Kidney Disease Epidemiology Collaboration Equation
- eGFR in Children
- Which eGFR equation is currently recommended for use by international experts?
- Urine Albumin
- Urine Albumin
- Urine Albumin/Creatinine Ratio
- Categories of Albuminuria
- True or False: The term "microalbumin" is currently recommended for use to describe urine albumin.
- Match the following categories of albuminuria to their respective urine albumin/creatinine ratio.
- Clinical Assessment and Treatment
- Clinical Assessment of Risk
- Treatment/Therapy
- Summary
- References
- References
Additional Information
Level of Instruction: Intermediate
Intended Audience: Medical laboratory scientists, medical laboratory technicians, laboratory supervisors, and laboratory managers. This course is also appropriate for MLS and MLT students and pathology residents.
Author Information: Kelly Wilhelms, PhD, DABCC, has over 15 years of diverse clinical laboratory experience in hospital and reference laboratories, ranging from various levels of general management to CLIA Laboratory Director. He is a veteran of over 10 years in the United States Army as a Biochemistry Officer and currently holds a high-level technical position at a major non-profit hospital system in the Southwestern US. Kelly holds a PhD in Toxicology from Iowa State University and is board certified by the American Board of Clinical Chemistry.
The author has no conflict of interest to disclose.
Reviewer Information:
Peter Platteborze, PhD, DABCC, FAACC, has over ten years of experience as a medical laboratory scientist, forensic toxicology expert witness, and laboratory director. He served over 20 years in the Army as a biochemist. He is currently a Program Director and Assistant Professor at St. Mary's University in San Antonio, TX. He holds a BS degree in Biochemistry from the University of Tampa and a PhD in Biochemistry from the University of South Carolina.
Joshua J. Cannon, MS, MLS(ASCP)CMSHCM received his Bachelor of Science and Master of Science in Medical Laboratory Science from Thomas Jefferson University in Philadelphia, PA. He holds Medical Laboratory Scientist and Specialist in Hematology certifications through the ASCP Board of Certification. He was a professor at Thomas Jefferson University for seven years before transitioning into his current role as Education Developer at MediaLab by Vastian. His areas of expertise and professional passions include clinical hematology and interprofessional education.
Course Description: This course provides essential background on chronic kidney disease (CKD) for the practicing clinical laboratorian. Emphasis is placed on the National Kidney Foundation Kidney Disease Outcomes Quality Initiative (NKF KDOQI) review and commentary of the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines, with focus on the laboratory testing associated with diagnosis and monitoring of the disease.