The Resistance Files Spotlight: Methicillin-Resistant Staphylococcus aureus
Continuing Education Credits
Objectives
- Describe the clinical significance and public health impact of methicillin-resistant Staphylococcus aureus (MRSA) in healthcare and community settings.
- Explain the molecular mechanism of methicillin resistance, including the role of mecA/mecC genes and altered penicillin-binding proteins.
- Identify appropriate laboratory methods for detecting MRSA and recognize common testing pitfalls that may lead to false susceptibility results.
- Select recommended antimicrobial susceptibility testing methods for MRSA and apply appropriate reporting practices.
- Summarize laboratory responsibilities related to infection control notification and communication when MRSA is detected.
Course Outline
- MRSA
- Clinical Relevance & Public Health Significance
- Mechanisms of Resistance
- Resistance Is Only Half the Story: Virulence Amplifies Impact
- Identification Strategies
- Workflow 1: Biochemical / Phenotypic Identification
- Workflow 2: MALDI-TOF MS Identification
- Workflow 3: Molecular Assays (mecA / mecC Detection)
- Susceptibility Interpretation & Stewardship-Focused Reporting
- Integrated Best-Practice Workflow
- Infection Control & Notification Requirements
- Key Takeaways
- References

