Myeloproliferative Neoplasms

Author: Leah Westover, MPH, MLS(ASCP)CM
Reviewer: Margaret Reinhart, MS, MLS(ASCP) and Joshua J. Cannon, MS, MLS(ASCP)CMSHCM
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Continuing Education Credits

P.A.C.E.® Contact Hours: 1 hour(s)

Florida Board of Clinical Laboratory Science CE Credit Hours

Florida Board of Clinical Laboratory Science CE - General (Hematology): 1 hour(s)

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Objectives

  • Describe the World Health Organization classification system for myeloproliferative neoplasms (MPNs).
  • Compare and contrast the types of MPNs based upon etiology and patient symptoms.
  • Discuss the hematologic, cytogenetic, and other laboratory features associated with specific MPNs.
  • List common treatment options for MPNs.

Course Outline

  • Myeloproliferative Neoplasms
    • Introduction to Myeloproliferative Neoplasms
    • Classification of MPNs
    • Pathophysiology of MPNs
    • Symptoms
    • Match the myeloproliferative neoplasm with the cell line that is most affected.
  • Chronic Myeloid Leukemia
    • Chronic Myeloid Leukemia
    • CML and the Philadelphia Chromosome
    • Laboratory Investigation of CML
    • Diagnosis of CML: Peripheral Blood Smear
    • CML Progression
    • CML Treatment
    • The Philadelphia chromosome associated with CML involves a reciprocal translocation of genes from which two chromosomes?
  • Chronic Neutrophilic Leukemia
    • Chronic Neutrophilic Leukemia
    • Chronic Neutrophilic Leukemia, continued
  • Chronic Eosinophilic Leukemia
    • Chronic Eosinophilic Leukemia
    • What causes the characteristic heart and/or lung damage frequently demonstrated in patients with chronic eosinophilic leukemia?
  • Essential Thrombocythemia
    • Essential Thrombocythemia
    • Diagnosis of ET
    • Diagnosis of ET: Bone Marrow Findings
    • Diagnosis of ET: WHO Criteria
    • ET Treatment
    • Which thrombocytic characteristic is not associated with ET?
  • Primary Myelofibrosis
    • Primary Myelofibrosis
    • Diagnosis of PMF
    • Diagnosis of PMF: WHO Criteria
    • PMF Treatment
    • Which red blood cell morphologic feature is associated with primary myelofibrosis?
  • Polycythemia Vera
    • Polycythemia Vera
    • Diagnosis of PV
    • PV Treatment
    • True or False: The primary WHO criteria for diagnosing PV are bone marrow morphology (hypercellularity with prominent erythroid, granulocytic, and megakaryocytic proliferation and pleomorphic mature megakaryocytes) and a JAK2 (V617F) or exon 12 mutation.
  • Myeloproliferative Neoplasm, Not Otherwise Specified
    • Myeloproliferative Neoplasm, Not Otherwise Specified
  • Juvenile Myelomonocytic Leukemia
    • Juvenile Myelomonocytic Leukemia
    • Diagnosis and Laboratory Findings in JMML
    • Prognosis and Treatment of JMML
    • All of the following are true statements about JMML except:
  • Summary
    • Laboratory Findings Associated with MPNs
  • References
    • References

Additional Information

Level of instruction: Intermediate

Intended Audience: Medical laboratory scientists, medical laboratory technicians, laboratory supervisors, and laboratory managers. This course is also appropriate for MLS and MLT students and pathology residents.
Author information: Leah Westover, MPH, MLS(ASCP)CM is a Program Director at MediaLab, Inc. Previously, she was the Director of the Medical Laboratory Science Program at St. Christopher’s Hospital for Children in Philadelphia, Pennsylvania. She holds a Master of Science in Public Health from Thomas Jefferson University.
The author has no conflict of interest to disclose. 
Reviewer information:
Margaret Reinhart, MS, MLS(ASCP) serves as Senior Lecturer Emerita in Biological Sciences at Saint Joseph's University (formerly University of the Sciences) in Philadelphia, PA, and served as Program Director of Medical Laboratory Science from 1990 to 2020. She also taught hematology, clinical immunology, parasitology, and other related courses. She is currently an adjunct medical laboratory science instructor at Pennsylvania Hospital in Philadelphia, PA. She holds a master's degree in biology and in health care administration.
Joshua J. Cannon, MS, MLS(ASCP)CMSHCM received his Bachelor of Science and Master of Science in Medical Laboratory Science from Thomas Jefferson University in Philadelphia, PA. He holds Medical Laboratory Scientist and Specialist in Hematology certifications through the ASCP Board of Certification. He was a professor at Thomas Jefferson University for seven years before transitioning into his current role as Education Developer at MediaLab by Vastian. His areas of expertise and professional passions include clinical hematology and interprofessional education.