Hematology Interfering Factors: Cold Agglutinin

Vastian Learning
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Continuing Education Credits

P.A.C.E.® Contact Hours: hour(s)

Florida Board of Clinical Laboratory Science CE Credit Hours

: hour(s)

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Objectives

  • Describe the mechanism by which cold agglutinins cause red blood cell (RBC) agglutination.
  • Identify complete blood count results and analyzer findings that may indicate cold agglutinin interference.
  • Explain why RBC count, hematocrit, and RBC indices may be affected by RBC agglutination.
  • Differentiate RBC agglutination from rouleaux formation on a peripheral blood smear.
  • Apply appropriate specimen-handling and troubleshooting procedures when cold agglutinin interference is suspected.

Course Outline

  • Hematology Interfering Factors: Cold Agglutinin
    • Hematology Interfering Factors
    • Cold Agglutinins
    • Why Agglutination Interferes With a CBC
    • Understanding CBC Results
    • Recognizing Cold Agglutinin Interference
    • The Role of the Peripheral Blood Smear
    • Troubleshooting a Suspected Cold Agglutinin Specimen
    • What If Warming Does Not Correct the Results?
    • Pre-Examination Considerations
    • Reporting Considerations
    • Key Takeaways
  • References
    • References

Additional Information

This is a mini course designed to enhance learning and reinforce existing knowledge. It does not provide continuing education (CE) credit. The purpose of this course is to support ongoing professional development and review.