Common Coagulopathies
Continuing Education Credits
This course addesses common coagulopathies and the laboratory testing used to diagnose and evaluate these disorders. Hemophilia A and B, Disseminated Intravascular Coagulation, VonWillebrand disease, and the Factor V Leiden mutation are explored. Lupus anticoagulants are discussed along with how they can be mitigated in laboratory analysis.
Objectives
- Explain the cause of Hemophilia A and B and describe the testing used to evaluate these conditions.
- Discuss the symptoms of Disseminated Intravascular Coagulation (DIC) and the laboratory testing used to help diagnose it.
- Describe the prevalence, pathology, and lab testing used to assess the Factor V Leiden mutation.
- Describe the different forms of von Willebrand's disease and the platelet testing used to assess this condition.
- Explain what a lupus anticoagulant is and how this interference can be identified and mitigated.
Course Outline
- Coagulopathies
- Introduction
- Hemophilia
- Hemophilia
- Hemophilia A
- Factor Activity Assays
- Lab Interference
- Hemophilia B
- Which is true of a patient who has a prolonged aPTT and a factor VIII activity assay of <5%?
- Emicizumab is relevant to the lab for which of the following reasons?
- Disseminated Intravascular Coagulation
- Fibrinolysis
- Measuring Fibrinolysis
- What is Disseminated Intravascular Coagulation?
- Diagnosing Disseminated Intravascular Coagulation
- Lab Results in DIC
- Which of the following would not be expected in a patient with DIC?
- Which of the following is true concerning fibrinolysis?
- Hypercoagulable Conditions
- Thromboembolism
- Protein C and S
- Protein C and S Resistance
- Testing for APC Resistance and Factor V Leiden
- Which of the following is true concerning Protein C and Protein S?
- A deep vein thrombosis is:
- Von Willebrand's Disease
- What is Von Willebrand's Disease?
- Types of VWD
- Testing for VWD
- Testing for VWD, continued
- Testing for VWD, continued
- Which of the following is true?
- Which of the following tests is not used in the work-up of VWD?
- Lupus Anticoagulant
- What is a Lupus Anticoagulant?
- APS versus LAC
- Testing for LAC
- A dRVVT that corrects with normal donor plasma suggests:
- True or False: Antiphospholipid syndrome is a hypercoagulable state caused by the presence of antibodies against phospholipids or phospholipid-binding proteins.
- References
- References
Additional Information
Level of Instruction: Intermediate
Intended Audience: Medical laboratory scientists, medical laboratory technicians, students, and those interested in reviewing the fundamentals of coagulation.
Author Information: Kevin F. Foley, PhD, MLS(ASCP)SC, DABCC is the director of clinical pathology for the Kaiser Permanente Northwest region. He also teaches clinical chemistry at Oregon Health Sciences University. Dr. Foley earned his PhD in clinical pharmacology and toxicology at the East Carolina School of Medicine in North Carolina. He received a PhD in clinical pharmacology and toxicology from Brody School of Medicine, Greenville, NC. He has been working in laboratory medicine for over 15 years, starting his career as a medical laboratory scientist.
Reviewer Information: Laurie Bjerklie, MA, MLS(ASCP)CM is
currently an Education Developer for MediaLab and LabCE. She earned a B.S. in
Medical Laboratory Science from the University of North Dakota and an M.A. in
Curriculum and Instruction from Saint Xavier University. She has over 15 years
of experience in higher education and has held program director and faculty
positions in both MLT and MLS programs.