Warm Antibodies and Autoantibodies in Blood Banking
Continuing Education Credits
This course explores warm antibodies and autoantibodies in blood banking. Warm autoimmune hemolytic anemia is covered along with techniques in the blood bank that can be used to detect underlying alloantibodies in patients with warm autoantibodies. Cold autoantibodies and disease associated with cold autoantibodies are discussed along with techniques to ensure the safety of transfusions.
Objectives
- Describe warm autoantibodies and warm autoimmune hemolytic anemia.
- State warm autoantibody techniques used in the blood bank to detect underlying alloantibodies.
- Discuss cold autoantibodies encountered in the blood bank and diseases associated with them.
- Explain techniques used in the blood bank when cold autoantibodies are suspected and how to safely transfuse a patient with cold autoantibodies.
Course Outline
- Panel Review
- Scenario
- Blood Bank Workup
- Which of the following could be used to describe an antibody reacting with all reagent cells of a panel, rather than individual cells?
- Warm Autoantibodies
- Warm Autoantibodies
- Warm Autoimmune Hemolytic Anemia
- What is the reaction temperature of warm autoantibodies?
- Warm Autoantibody Workup
- What Do You Do if You Suspect a Warm Autoantibody?
- Direct Antiglobulin Test
- Direct Antiglobulin Test Procedure
- Elution
- Elution
- Elution Procedure
- Adsorption
- Adsorption
- Autoadsorption
- Allogeneic Adsorption
- Transfusion Recommendations
- Crossmatch and Transfusion
- Which technique removes antibodies that are attached to the surface of red blood cells?
- Cold Autoantibodies
- Cold Antibodies
- Cold Autoantibodies
- Autoanti-P
- Donath-Landsteiner Test Procedure
- Autoanti-I
- Autoanti-i
- What temperature does Autoanti-P react at?
- Cold Agglutinin Disease (CAD)
- Testing for Cold Agglutinin Disease in the Blood Bank
- Cold Agglutinin Titer
- Thermal Amplitude
- ABO Testing with Cold Autoantibodies
- Antibody Testing with Cold Autoantibodies
- Conclusion
- Conclusion
- References
- References
Additional Information
Level of Instruction: Intermediate
Intended Audience: Medical laboratory scientists, medical laboratory technicians, laboratory supervisors, and laboratory managers. This course is also appropriate for MLS and MLT students and pathology residents.
Author Information: Laurie Flood, BS, MLS(ASCP)CM, currently works as the Laboratory Coordinator for Lehigh Valley Physician Group in Allentown, PA.
Reviewer Information:
Sheri Goertzen, MLS(ASCP)BB, CLS(CA), CQA(ASQ), has over 25 years of experience as the Supervisor of Transfusion Services at Valley Children's Healthcare in Madera, CA. She has almost 40 years of experience in transfusion services. She has been a presenter at AABB conferences and has served on several AABB committees as a contributing member or the committee chair.
Laurie Bjerklie, MA, MLS(ASCP)CM is
currently an Education Developer for MediaLab and LabCE. She earned a B.S. in
Medical Laboratory Science from the University of North Dakota and an M.A. in
Curriculum and Instruction from Saint Xavier University. She has over 15 years
of experience in higher education and has held program director and faculty
positions in both MLT and MLS programs
Course Description: This course explores warm antibodies and autoantibodies in blood banking. Warm autoimmune hemolytic anemia is covered along with techniques in the blood bank that can be used to detect underlying alloantibodies in patients with warm autoantibodies. Cold autoantibodies and diseases associated with cold autoantibodies are discussed along with techniques to ensure the safety of transfusions.