Chronic Myeloid Leukemia
Continuing Education Credits
Objectives
- Define chronic myeloid leukemia (CML).
- Describe the epidemiology and etiology of CML.
- Discuss the site of involvement and clinical features of CML.
- Describe the peripheral blood findings and blood smear morphology for CML cases.
- Describe the bone marrow morphology in patients with CML.
- List the disease stages in patients with CML.
- Discuss immunophenotyping and cytogenetics for CML cases.
- Outline the prognosis and therapy for patients with CML.
- Outline the prognosis and therapy for patients with CML.
- Outline the prognosis and therapy for patients with CML.
Course Outline
- An Introduction to Chronic Myeloid Leukemia
- Introduction to Chronic Myeloid Leukemia
- Progression of Chronic Myeloid Leukemia
- Progression of Chronic Myeloid Leukemia, continued
- CML is caused by which of the following?
- The Philadelphia (Ph) chromosome is associated with which of the following chromosomal translocations?
- True or False: The latest World Health Organization (WHO) Classification of Myeloid Neoplasms (2022) categorizes CML into three phases: chronic phase, accelerated phase, and blast phase.
- True or False: CML does not transform into acute leukemia.
- Epidemiology and Risk Factors of Chronic Myeloid Leukemia
- Epidemiology and Risk Factors
- True or False: Patients with CML may initially have symptoms of weight loss, low-grade fever, night sweats, or no symptoms at all.
- True or False: CML is only a disease of children and is rarely seen in adults.
- Which of the following options best describes CML?
- Site of Involvement and Clinical Features for Chronic Myeloid Leukemia
- Sites of Involvement and Clinical Features
- True or False: CML patients in CP commonly present with very low WBC and platelet counts.
- True or False: Splenomegaly is common in CP of CML.
- Peripheral Blood and Bone Marrow Morphology
- Morphology of the Peripheral Blood Smear
- Morphology of the Bone Marrow Aspirate Smear
- Morphology of the Bone Marrow Aspirate Smear, continued
- CML patients in CP commonly present with all of the following except:
- Cytogenetics, Immunophenotyping, and Polymerase Chain Reaction
- Polymerase Chain Reaction
- Cytogenetics
- Cytogenetics, continued
- Immunophenotyping
- Cytochemical Staining
- Cytochemical Staining, continued
- True or False: Immunophenotyping is very valuable in BP to distinguish myeloid, lymphoid, or mixed phenotype blasts.
- True or False: Leukocyte alkaline phosphatase activity (LAP score) is very strong in CML and weak in leukemoid reaction.
- Differential Diagnosis
- Differential Diagnosis
- True or False: Patients with CML and leukemoid reaction present with leukocytosis.
- True or False: CML resembles a leukemoid reaction in many ways and is usually resolved with antibiotics.
- Prognosis and Therapy
- Prognosis and Therapy
- Prognosis and Therapy, continued
- True or False: Currently, there is no therapy for CML.
- References
- References
Additional Information
Level of instruction: Intermediate
Intended audience: Medical laboratory scientists, medical laboratory technicians, laboratory supervisors, and laboratory managers. This course is also appropriate for MLS and MLT students and pathology residents.
Author Information: George Girgis, MLS (ASCP)CM has over 30 years of experience as a medical laboratory scientist, during which he has been a trainer and instructor at Indiana University Health in the field of hematology and hematopathology. George holds a Bachelor of Medicine, Bachelor of Surgery from Ein-Shams University, Cairo, Egypt and a Bachelor of Science in Medical Laboratory Sciences from I.U.P.U.I., Indianapolis, IN.
The author has no conflict of interest to disclose.
Reviewer Information:
Joshua J. Cannon, MS, MLS(ASCP)CMSHCM received his Bachelor
of Science and Master of Science in Medical Laboratory Science from Thomas
Jefferson University in Philadelphia, PA. He holds Medical Laboratory Scientist
and Specialist in Hematology certifications through the ASCP Board of
Certification. He was a professor at Thomas Jefferson University for seven
years before transitioning into his current role as Education Developer at
MediaLab. His areas of expertise and professional passions include clinical
hematology and interprofessional education.
Laurie Bjerklie, MA, MLS(ASCP)CM is a Lead Education Developer. She earned a B.S. in Medical Laboratory Science from the University of North Dakota and an M.A. in Curriculum and Instruction from Saint Xavier University. She has over 15 years of experience in higher education and has held program director and faculty positions in both MLT and MLS programs.